COVID - 19 Vaccination Research
This research is taking place at Halton Hospital
You can find out more about the study and sign up by following this link
Join a COVID-19 clinical trial
The PRINCIPLE trial aims to find treatments that reduce hospital admission and improve symptoms for people with COVID-19. You could be eligible to join if:
- You have had these symptoms for fewer than 15 days:
· new continuous cough or high temperature or a loss of, or change in, normal sense of taste or smell
- OR have a positive test for SARS-Co-V2 infection with COVID-19 symptoms in the past 14 days
· You are aged 65 and above,
· OR 18-64 and experiencing shortness of breath as part of COVID-19 illness,
· OR 18-64 with certain underlying health conditions.
Find out more https://www.principletrial.org/
Semaglutide effects on heart disease and stroke in patients with overweight or obesity
The researchers are doing the study to see if semaglutide may reduce the risk of having cardiovascular events in patients with overweight or obesity and with prior cardiovascular disease. The participant will either get semaglutide (active medicine) or placebo (“dummy” medicine). Which treatment the participants get is decided by chance. The participant’s chance of getting semaglutide or placebo is the same. The participant will get the study medicine in a pen. The participants will need to use the pen to inject the study medicine in a skinfold once a week. The study will last for about 2.5 to 5 years. Participants will have up to 25 clinic visits with the study doctor.
Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke (VESALIUS-CV)
This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a cardiovascular event.
GlaxoSmithKline Shingles Study
Have you had Shingles in the past?
Are you interested in taking part in a GlaxoSmithKline sponsored study looking at the use of a vaccine to prevent another shingles attack in the future?
If you’re aged 50 and over, and have had Shingles once before please get in touch.
The Active Brains Study
A quick summary of the study
· This study is testing an interactive programme (called ‘Active Brains’) to help people aged 60-85 with lifestyle changes and brain training activities which may help with memory and thinking skills.
· If you take part, the study will last for five years.
· We ask everyone who takes part to complete 4 online puzzle games and answer some questions about how they are when they start the study, and then again each year after that. Doing these online puzzle games each year is a really important part of the study, and only takes about 10 minutes.
· About two thirds of people will be in a group who can use Active Brains straight away and one third of people will carry on with usual care and get brief advice about a healthy lifestyle.
· Which group you are in will be decided by chance.
· Everyone in the study will carry on receiving their usual NHS care.
· The activities recommended by Active Brains can nearly all be done at home. They are all activities that are likely to be good for staying fit and healthy in general. However, it is very important to follow current government advice about how to stay safe and healthy during the Coronavirus (COVID-19) outbreak.
The study is being run by the University of Southampton and is funded by the National Institute for Health Research, the main funder of research in the NHS.
PANDA-S: Prognostic AND Diagnostic Assessment of Shoulder Pain research study
Shoulder problems affect 20% of adults and are often very painful, affecting sleep, work, and everyday life. Most patients receive treatment from GPs or physiotherapists, but 7 times more patients are having surgery compared with 10 years ago. There is no evidence that surgery provides better results than non-surgical treatments such as shoulder exercises.
In order to develop and test a better approach to assessing the likely cause (diagnosis) and future outcome (prognosis) of shoulder problems we aim to recruit 1000 patients consulting their GP or self-referring to physiotherapy with shoulder pain to a follow-up study. Their GPs and physiotherapists will continue to treat them in the way they feel is most appropriate. Willing participants will complete 6 questionnaires on pain, difficulties with everyday activities, treatments, and quality of life over 3 years, providing unique information about long-term outcomes. They will also be invited to attend an optional clinical assessment including an ultrasound scan of the shoulder and/or complete an optional app or respond to text messages once a week for 12 weeks to provide short term information on shoulder pain and difficulties with everyday activities. They will additionally be invited to participate in an optional interview about their shoulder pain.
Click here for further study details
PROP-OA – A trial of advice, exercise and braces for adults aged 45 and over with knee pain and knee osteoarthritis
Are you 45 or older? Do you experience knee pain?
If you answered yes to both of the above questions, then you may be eligible to take part in the PROP-OA study – a clinical trial that is testing advice, exercise and knee braces in older adults.
Please explore this website to find out more information about the PROP-OA trial. To see if you can take part please call the PROP-OA research team on Freephone 0800 130 3419.
Click here for further study details
Is a research register that anyone over 18yrs can sign up, if they are interested in hearing about and
taking part in Irritable Bowel Syndrome (IBS) research.
Click here for further study details
“The aim of this trial is to compare the effectiveness and cost effectiveness of brief messaging to support patients with type 2 diabetes taking diabetes medicine (glucose, blood pressure, or lipid lowering) in reducing risk factors for diabetes complications, with usual care”
Expression of interest
Text Register first & last name (e.g. Register John Smith) to 07800 002507
* Email: firstname.lastname@example.org; email@example.com
* (Phone the trial team: (OX) 0808 164 2521; (MA) 07423 741836)
*If EOI received by email or telephone patients will be asked to text their full name.
Participants MUST NOT be randomised unless a text has been receive
PROMDEP RCT (Patient-reported outcome measures for monitoring primary care patients with depression: PROMDEP randomised controlled trial)
The PROMDEP RCT will look at whether giving personal feedback to people being treated for depression might help them get better more quickly. This will be done by using the PHQ-9 depression symptom questionnaire as a patient reported outcome measure (or ‘PROM’) and feeding back the results to the patients themselves, and the practitioners looking after them, together with brief suggestions for treatment relevant to the severity of the patient’s depression.
The aim is to answer the following research question: What is the effectiveness and cost- effectiveness of assessing primary care patients with depression or low mood soon after diagnosis and again at follow-up 10-35 days later, using the PHQ-9 questionnaire combined with patient and practitioner feedback and guidance on treatment?
To get in touch: Email: PROMDEP@liverpool.ac.uk